MLCK/actin interaction in contracting rat aortic smooth muscle
نویسندگان
چکیده
منابع مشابه
Receptors in Cultured Rat Aortic Smooth Muscle Cells
Previous studies have demonstrated increased contractile responses to thromboxane A2 (TXA2) mimetics in aortas obtained from male rats compared with those obtained from females. This study was designed to determine the effects of testosterone and 17p-estradiol treatment on TXA2 receptors in cultured rat aortic smooth muscle cells (RASMCs). TXA2 receptor affinity and density were determined thro...
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In different experimental models, retinoid has been shown to stimulate or suppress mitogenesis in cultured cells. The mechanisms underlying this seemingly paradoxical activity remain only partially understood. We have examined the ability of alltrans retinoic acid (ATRA), as well as a number of synthetic retinoids, either alone or in the presence of a mitogenic stimulus (i.e., endothelin), to r...
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PURPOSE To examine the effect of halothane on the cytosolic Ca2+ concentration ([Ca2+]i)-tension relationship of rat aortic smooth muscle. METHODS Rat aortic rings without endothelia were loaded with the fluorescent Ca2+ indicator, Fura PE3-AM, and then mounted in organ baths. The changes in isometric tension and [Ca2+]i were measured simultaneously. In one series ionomycin (10 nM-3 microM) w...
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OBJECTIVE This study aims to observe the contraction role of RELMα in rat aortic smooth muscle cells and explore its mechanism. METHODS Rat aortas smooth muscle cells were cultivated using tissue explants method. They were divided into 5 groups. A: Control group; B: 1×10(-7) mol/L ANGII group; C: 1×10(-8) mol/L RELMα group; D: 2×10(-8) mol/L RELMα group; E: 4×10(-8) mol/L RELMα group. The tho...
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Leptin, a peptide secreted from adipose tissue, plays an important role in the regulation of food intake and energy expenditure. In obese patients, plasma leptin levels are elevated and obesity is one of the major risk factors for cardiovascular diseases. Therefore, in this study, we investigated the effect of leptin on vascular smooth muscle cell (VSMC) functions. Cultured rat aortic VSMC expr...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2007
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.21.6.a1301-b